Anyone who’s even slightly attuned to developments in the ‘trending foods’ space are surely aware of the surging popularity of functional mushrooms like lion’s mane, reishi and cordyceps.
Many of the purported health benefits that have been talked about for years are now supported by scientific research, and medical professionals increasingly are encouraging the consumption of these varieties, whether they’re ingested through foods, drinks, supplements, topicals or other means.
Used for centuries in traditional medicine, the dynamic mushrooms offer a range of effects from cognitive enhancement to immune regulation. While their mechanisms vary, they share anti-inflammatory and antioxidant properties that support overall wellness.

Lion’s mane (hericium erinaceus) is best known for its impact on brain health. Compounds called hericenones and erinacines stimulate the production of nerve growth factor (NGF), which supports the growth and repair of nerve cells. Clinical studies have shown that lion’s mane may improve cognitive function in people with mild cognitive impairment and potentially reduce symptoms of anxiety and depression, likely due to its neuroregenerative effects.
Reishi (ganoderma lucidum) acts as a powerful adaptogen and immune modulator. It helps balance the immune system by either stimulating or suppressing immune activity as needed. Reishi has shown promise in improving sleep quality, reducing fatigue and enhancing well-being in cancer patients undergoing treatment. Some research also supports its use in promoting liver health and reducing inflammation.
Cordyceps (cordyceps militaris and sinensis) are commonly used to enhance energy and stamina. It supports the production of ATP, the body’s primary energy molecule, which may explain improved exercise performance and oxygen utilization observed in some studies. Cordyceps also help regulate blood sugar levels and support immune system function, making it a favorite among athletes and those with metabolic concerns.
Across the board, these functional mushrooms exhibit anti-inflammatory, antioxidant and immune-balancing effects that contribute to long-term health. Though benefits often build gradually with consistent use, the safety profile for most people is favorable. Of course, individuals with autoimmune conditions, mushroom allergies or who are pregnant should consult a healthcare provider before use.
As research continues, the potential of these mushrooms in areas like neurodegeneration, metabolic health and cancer treatment support looks increasingly promising. While not a replacement for conventional treatment, lion’s mane, reishi and cordyceps represent powerful natural tools that can complement a wellness regimen rooted in evidence-based practices.